Bioactive composite ceramics in the hydroxyapatitetricalcium phosphate system
O. L. Kubarev, V. S. Komlev, M. Maitz, S. M. Barinov
Synthetic materials based on hydroxyapatite (HA), an analogue of the mineral component of the bone tissue, are used in medicine for the repair of damaged bone tissue. A new repair technology is based on implanting porous ceramic
scaffolds containing cultivated cells and proteins into the bone tissue. The formation of new bone tissue is a complex process that includes protein adsorption as an important stage. Scaffolds should be resorbable with time in the human body with gradual replacement by newly formed bone tissue and should ensure a high protein-adsorption capacity. Hydroxyapatite is stable against dissolution by body fluids, whereas tricalcium phosphate (TCP) has a much higher resorption rate compared to that
of HA. By varying the component ratio in an HA/TCP composite, one can control the resorption rate. The problems of design of such composite materials have been considered in reviews. Two-phase composites (TCMs) are produced by thermal decomposition of calcium-deficient HA followed by sintering. Using this method, it is difficult to control the component ratio in the material. Some aspects of the influence of the phase composition on the biological behavior of TCMs remain obscure. This study
is devoted to the production of TCMs with specified composition and porosity and elucidation of the question of which factor, porosity or phase composition, is more important for protein adsorption.